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American Society of Microbiology ABMM Sample Questions:

1. A patient with a history of exposure to bats in a cave develops progressive neurological symptoms, including hydrophobia. The MOST likely viral etiology is:

A) Japanese encephalitis virus
B) West Nile virus
C) Rabies virus
D) Herpes simplex virus encephalitis

2. A patient with HIV infection and a CD4+ T-cell count below 50 cells/µL develops a progressive neurological illness characterized by confusion, motor deficits, and seizures. Brain MRI reveals multiple white matter lesions without mass effect. PCR of the CSF is positive for JC virus. Thepathogenesis of this condition, progressive multifocal leukoencephalopathy (PML), involves:

A) Lytic infection of oligodendrocytes by JC virus, leading to demyelination.
B) Inflammatory demyelination triggered by JC virus infection of astrocytes.
C) Direct cytopathic effect of JC virus on neurons.
D) Opportunistic infection by JC virus due to impaired cell-mediated immunity.

3. The primary mechanism of action of aminoglycoside antibiotics, such as gentamicin, involves:

A) Disruption of bacterial cell membrane integrity
B) Inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit
C) Inhibition of bacterial DNA gyrase and topoisomerase IV
D) Inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins

4. A traveler returning from a tropical region presents with fever, chills, and jaundice. Peripheral blood smear reveals the presence of ring-shaped parasites within erythrocytes. Further laboratory testing shows a positive result for Plasmodium falciparum histidine-rich protein 2 (HRP2). The MOST appropriate treatment for this patient is:

A) Metronidazole
B) Mebendazole
C) Amphotericin B
D) Primaquine and a blood schizonticide (e.g., artemisinin-based combination therapy)

5. A patient develops a localized skin infection after being bitten by a tick. The infection is characterized by a slowly expanding erythematous rash with central clearing (erythema migrans). The MOST likely causative agent is:

A) Rickettsia rickettsii
B) Anaplasma phagocytophilum
C) Borrelia burgdorferi
D) Ehrlichia chaffeensis

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